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Senior Upstream Scientist

We are currently looking for a Senior Upstream Scientist to join a leading biopharmaceutical company based in the Berkshire area.

As the Senior Scientist you will be joining the Upstream Process Development Team, focusing your work on microbial upstream process development and plasmid production.


Your duties as the Senior Upstream Scientist will be varied however the key duties and responsibilities are as follows:


You will develop microbial upstream processes for plasmid DNA production as an input into gene therapy products


As the Senior Upstream Scientist, you will be responsible for identifying scale-up challenges and developing robust upstream processes for tech transfer to manufacturing scale, as well as developing and optimising efficient microbial fermentation, lysis and primary recovery steps


You will work with equipment of varying levels, including shake flasks, ambr250, 5L and 200L scales


It will be your responsibility to evaluate equipment improvements for automation and process operations and sampling


To be successful in your application to this exciting opportunity as the Senior Upstream Scientist, we are looking to identify the following on your profile and past history:


Essentially, you will have a relevant degree in a biochemistry related subject (e.g.

biochemical engineering, biotechnology, cellular biology, biochemistry, molecular biology, etc) and a PhD is highly desirable


Proven industry experience in an upstream process development setting, working with bioreactors and fermenters is necessary


A working knowledge and practical experience with primary recovery operations for the development of plasmid DNA or biologics products is required

Key Words: Upstream | Senior Scientist | Fermentation | Microbial | Bioreactor | Ambr | Production | Plasmid | DNA | Biochemistry | Biologics | Biopharmaceutical | Biochemical Engineering | Process Development | Gene Therapy | AAV | Manufacturing | USP

Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer who are certified by Investors in People for talent development.

We therefore welcome applications for any interested parties who fulfil the role requirements for this position.

HRS is a company exclusively supporting the science and technology sectors, and is made up of a collaboration of recruitment professionals and scientists.

We look forward to helping you with your next career moves.